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Publications

  • Systems profiling reveals recurrently dysregulated cytokine signaling responses in ER+ breast cancer patients’ blood. B. Orcutt-Jahns, J. R. L. Junior, R. C. Rockne, A. Matache, S. Branciamore, E. Hung, A. S. Rodin, P. P. Lee, & A. S. Meyer. (2023). Submitted. [Abstract]
  • Dissecting signaling regulators driving AXL-mediated bypass resistance and associated phenotypes by phosphosite perturbations. M. Creixell, S. D. Taylor, J. Gerritsen, S. Y. Bae, M. Jiang, T. Augustin, M. Loui, C. Boixo, P. Creixell, F. M. White, & A. S. Meyer. (2023). Submitted. [Abstract]
  • Multivalent, asymmetric IL-2–Fc fusions show enhanced selectivity for regulatory T cells. B. Orcutt-Jahns, P. C. Emmel, E. M. Snyder, S. D. Taylor, & A. S. Meyer. (2023). Science Signaling. [Abstract]
  • Synthetic living materials in cancer biology. S. R. Peyton, L. W. Chow, S. D. Finley, A. N. F. Versypt, R. Hill, M. L. Kemp, E. M. Langer, A. P. McGuigan, A. S. Meyer, S. K. Seidlits, K. Roy, & S. M. Mumenthaler. (2023). Nature Reviews Bioengineering. [Abstract]
  • Disulfide-HMGB1 signals through TLR4 and TLR9 to induce inflammatory macrophages capable of innate-adaptive crosstalk in human liver transplantation. A. Q. Terry, H. Kojima, R. A. Sosa, F. M. Kaldas, J. L. Chin, Y. Zhenga, B. V. Naini, D. Noguchi, J. Nevarez-Mejia, Y.-P. Jin, R. W. Busuttil, A. S. Meyer, D. W. Gjertson, J. W. Kupiec-Weglinski, & E. F. Reed. (2023). American Journal of Transplantation. [Abstract]
  • Mixed IgG Fc immune complexes exhibit blended binding profiles and refine FcR affinity estimates. Z. C. Tan, A. Lux, M. Biburger, P. Varghese, S. Lees, F. Nimmerjahn, & A. S. Meyer. (2023). Cell Reports. [Abstract]
  • Analysis and modeling of cancer drug responses using cell cycle phase-specific rate effects. S. M. Gross, F. Mohammadi, C. Sanchez-Aguila, P. J. Zhan, A. S. Meyer, & L. M. Heiser. (2023). Nature Communications. [Abstract]
  • Tensor-based insights into systems immunity and infectious disease. J. L. Chin, L. C. Chan, M. R. Yeaman, & A. S. Meyer. (2023). Trends in Immunology. [Abstract]
  • Design of cell-type-specific hyperstable IL-4 mimetics via modular de novo scaffolds. H. Yang, U. Y. Ulge, A. Quijano-Rubio, Z. J. Bernstein, J. David R. Maestas, J.-H. Chun, W. Wang, J.-X. Lin, K. M. Jude, S. Singh, B. T. Orcutt-Jahns, P. Li, J. Mou, L. Chung, Y.-H. Kuo, Y. H. Ali, A. S. Meyer, W. L. Grayson, N. M. Heller, K. C. Garcia, … J. B. Spangler. (2023). Nature Chemical Biology. [Abstract]
  • A stimulus-contingent positive feedback loop enables IFN-β dose-dependent activation of pro-inflammatory genes. C. Wilder, D. Lefaudeux, R. Mathenge, K. Kishimoto, A. Z. Munoz, M. A. Nguyen, A. S. Meyer, Q. J. Cheng, & A. Hoffmann. (2023). Molecular Systems Biology. [Abstract]
  • Addressing the genetic/nongenetic duality in cancer with systems biology. P. Kulkarni, H. S. Wiley, H. Levine, H. Sauro, A. Anderson, S. T. C. Wong, A. S. Meyer, P. Iyengar, K. Corlette, K. Swanson, A. Mohanty, S. Bhattacharya, A. Patel, V. Jain, & R. Salgia. (2023). Trands in Cancer. [Abstract]
  • Live Cell Lineage Tracing of Dormant Cancer Cells. H. Kim, A. Wirasaputra, F. Mohammadi, A. N. Kundu, J. A. E. Esteves, L. M. Heiser, A. S. Meyer, & S. R. Peyton. (2023). Advanced Healthcare Materials. [Abstract]
  • Cytokine-expression patterns reveal coordinated immunological programs associated with persistent MRSA bacteremia. J. L. Chin, Z. C. Tan, L. C. Chan, F. Ruffin, R. Parmar, R. Ahn, S. Taylor, A. S. Bayer, A. Hoffmann, J. Vance G Fowler, E. F. Reed, M. R. Yeaman, A. S. Meyer, & MRSA Systems Immunobiology Group. (2022). Submitted. [Abstract]
  • A lineage tree-based hidden Markov model to quantify cellular heterogeneity and plasticity. F. Mohammadi, S. Visagan, S. M. Gross, L. Karginov, J. C. Lagarde, L. M. Heiser, & A. S. Meyer. (2022). Communications Biology. [Abstract]
  • Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection. D. VanDyke, M. Iglesias, J. Tomala, A. Young, J. Smith, J. A. Perry, E. Gebara, A. R. Cross, L. S. Cheung, A. G. Dykema, B. T. Orcutt-Jahns, T. Henclová, J. Golias, J. Balolong, L. M. Tomasovic, D. Funda, A. S. Meyer, D. M. Pardoll, J. Hester, F. Issa, … J. B. Spangler. (2022). Cell Reports. [Abstract]
  • Systems approaches to uncovering the contribution of environment-mediated drug resistance. M. Creixell, H. Kim, F. Mohammadi, S. R. Peyton, & A. S. Meyer. (2022). Current Opinion in Solid State and Materials Science. [Abstract]
  • Dual data and motif clustering improves the modeling and interpretation of phosphoproteomic data. M. Creixell, & A. S. Meyer. (2022). Cell Reports Methods. [Abstract]
  • Integrated proteomics-based physical and functional mapping of AXL kinase signaling pathways and inhibitors define its role in cell migration. A. Majumder, S. Hosseinian, M. J. Stroud, E. Adhikari, J. J. Saller, D. M. A. Smith, D. G. Zhang, S. Agarwal, M. Creixell, B. S. Meyer, M. F. Kinose, K. S. Bowers, B. Fang, P. A. Stewart, E. A. Welsh, T. A. Boyle, A. S. Meyer, J. M. Koomen, & E. B. Haura. (2022). Molecular Cancer Research. [Abstract]
  • A quantitative view of strategies to engineer cell-selective ligand binding. Z. C. Tan, B. T. Orcutt-Jahns, & A. S. Meyer. (2021). Integrative Biology. [Abstract]
  • Tensor-structured decomposition improves systems serology analysis. Z. C. Tan, M. Murphy, H. S. Alpay, S. D. Taylor, & A. S. Meyer. (2021). Molecular Systems Biology. [Abstract]
  • Modeling Cell-Specific Dynamics and Regulation of the Common Gamma Chain Cytokines. A. M. Farhat, A. C. Weiner, C. Posner, Z. S. Kim, S. M. Carlson, & A. S. Meyer. (2021). Cell Reports. [Abstract]
  • A general model of multivalent binding with ligands of heterotypic subunits and multiple surface receptors . Z. C. Tan, & A. S. Meyer. (2021). Mathematical Biosciences. [Abstract]
  • Measurement and models accounting for cell death capture hidden variation in compound response. S. Y. Bae, N. Guan, R. Yan, K. Warner, S. D. Taylor, & A. S. Meyer. (2020). Cell Death & Disease. [Abstract]
  • An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence . C.-H. Lee, T. H. Kang, O. Godon, M. Watanabe, G. Delidakis, C. M. Gillis, D. Sterlin, D. Hardy, M. Cogné, L. E. Macdonald, A. J. Murphy, N. Tu, J. Lee, J. R. McDaniel, E. Makowski, P. M. Tessier, A. S. Meyer, P. Bruhns, & G. Georgiou. (2019). Nature Communications. [Abstract]
  • Systems biology approaches to measure and model phenotypic heterogeneity in cancer. A. S. Meyer, & L. M. Heiser. (2019). Current Opinion in Systems Biology. [Abstract]
  • Versatile targeting system for lentiviral vectors involving biotinylated targeting molecules. K. Situ, B. A. Chua, S. Y. Bae, A. S. Meyer, & K. Morizono. (2018). Virology. [Abstract]
  • Systems Modeling Identifies Divergent Receptor Tyrosine Kinase Reprogramming to MAPK Pathway Inhibition . A. M. Claas, L. Atta, S. Gordonov, A. S. Meyer, & D. A. Lauffenburger. (2018). Cellular and Molecular Bioengineering. [Abstract]
  • Human induced pluripotent stem cell-derived glial cells and neural progenitors display divergent responses to Zika and dengue infections . J. Muffat, Y. Li, A. Omer, A. Durbin, I. Bosch, G. Bakiasi, E. Richards, A. Meyer, L. Gehrke, & R. Jaenisch. (2018). Proceedings of the National Academy of Sciences. [Abstract]
  • Dissecting FcγR Regulation Through a Multivalent Binding Model. R. A. Robinett, N. Guan, A. Lux, M. Biburger, F. Nimmerjahn, & A. S. Meyer. (2018). Cell Systems. [Abstract]
  • Apoptotic Bodies Elicit Gas6-mediated Migration of AXL-expressing Tumor Cells. A. Zweemer, C. B. French, J. Mesfin, S. Gordonov, A. S. Meyer, & D. A. Lauffenburger. (2017). Molecular Cancer Research. [Abstract]
  • A Biomaterial Screening Approach to Reveal Microenvironmental Mechanisms of Drug Resistance. A. D. Schwartz, L. E. Barney, L. E. Jansen, T. V. Nguyen, C. L. Hall, A. S. Meyer, & S. Peyton. (2017). Integrative Biology. [Abstract]
  • Systems Approaches to Cancer Biology. T. C. Archer, E. J. Fertig, S. J. C. Gosline, M. Hafner, S. K. Hughes, B. A. Joughin, A. S. Meyer, S. R. Piccolo, & A. N. Shajahan-Haq. (2016). Cancer Research. [Abstract]
  • JNK Pathway Activation Modulates Acquired Resistance to EGFR/HER2-Targeted Therapies. S. Manole, E. J. Richards, & A. S. Meyer. (2016). Cancer Research. [Abstract]
  • Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance . M. A. Miller, M. J. Oudin, R. J. Sullivan, S. J. Wang, A. S. Meyer, H. Im, D. T. Frederick, J. Tadros, L. G. Griffith, H. Lee, R. Weissleder, K. T. Flaherty, F. B. Gertler, & D. A. Lauffenburger. (2016). Cancer Discovery. [Abstract]
  • A requirement for filopodia extension toward Slit during Robo-mediated axon repulsion. R. E. McConnell, J. E. V. Veen, M. Vidaki, A. V. Kwiatkowski, A. S. Meyer, & F. B. Gertler. (2016). Journal of Cell Biology. [Abstract]
  • Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain . M. A. Miller, M. L. Moss, G. Powell, R. Petrovich, L. Edwards, A. S. Meyer, L. G. Griffith, & D. A. Lauffenburger. (2015). Scientific Reports. [Abstract]
  • Selectivity in Subunit Composition of Ena/VASP Tetramers. D. N. Riquelme, A. S. Meyer, M. Barzik, A. Keating, & F. Gertler. (2015). Bioscience Reports. [Abstract]
  • The AXL Receptor Is a Sensor of Ligand Spatial Heterogeneity. A. S. Meyer, A. J. M. Zweemer, & D. A. Lauffenburger. (2015). Cell Systems. [Abstract]
  • The Receptor AXL Diversifies EGFR Signaling and Limits the Response to EGFR-Targeted Inhibitors in Triple-Negative Breast Cancer Cells . A. S. Meyer, M. A. Miller, F. B. Gertler, & D. A. Lauffenburger. (2013). Science Signaling. [Abstract]
  • ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling. . M. A. Miller, A. S. Meyer, M. T. Beste, Z. Lasisi, S. Reddy, K. W. Jeng, C.-H. Chen, J. Han, K. Isaacson, L. G. Griffith, & D. A. Lauffenburger. (2013). Proc Natl Acad Sci U S A. [Abstract]
  • 2D protrusion but not motility predicts growth factor–induced cancer cell migration in 3D collagen . A. S. Meyer, S. K. Hughes-Alford, J. E. Kay, A. Castillo, A. Wells, F. B. Gertler, & D. A. Lauffenburger. (2012). The Journal of Cell Biology. [Abstract]
  • Fluorinert, an oxygen carrier, improves cell culture performance in deep square 96-well plates by facilitating oxygen transfer . A. Meyer, R. G. G. Condon, G. Keil, N. Jhaveri, Z. Liu, & Y.-S. Tsao. (2012). Biotechnology Progress. [Abstract]
  • Signaling network state predicts Twist-mediated effects on breast cell migration across diverse growth factor contexts . H.-D. Kim, A. S. Meyer, J. P. Wagner, S. K. Alford, A. Wells, F. B. Gertler, & D. A. Lauffenburger. (2011). Molecular & Cellular Proteomics. [Abstract]
  • Integrated Pathway Analysis of Genome-Wide Expression Changes Associated with Serum-Free Suspension Adaptation of an Antibody-Producing Chinese Hamster Ovary (CHO) Cell Line . Y.-S. Tsao, A. A. Merchant, A. Meyer, Z. Liu, M. Smith, D. Levitan, & E. Gustafson. (2010). In Animal Cell Technology: Basic & Applied Aspects.
  • Concentration of mammalian genomic DNA using two-phase aqueous micellar systems. F. Mashayekhi, A. S. Meyer, S. A. Shiigi, V. Nguyen, & D. T. Kamei. (2009). Biotechnology and Bioengineering. [Abstract]
  • Enhancing the Detection of Urinary Tract Infections Using Two-Phase Aqueous Micellar Systems. S. A. Shiigi, A. S. Meyer, & D. T. Kamei. (2009). The UCLA USJ. [Abstract]