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Meyer Lab at UCLA

We pair experiments with data-driven modeling to learn about cancer biology and innate immune signaling. This combination is necessary and synergistic: models in systems biology are only as good as the information used to assemble them. As our understanding of biology begins to assemble from information about single proteins, we need quantitative models to understand and even communicate these complex processes.


Opportunities


News

Welcome to Jackson Chin! He previously studied bioengineering at University of Washington, and is joining the lab for his Ph.D.

Dr. Meyer will talk about the lab’s efforts for modeling tumor cell heterogeneity and AXL-driven drug resistance at Vanderbilt’s CSBC program.

The lab has been awarded a grant from the Jayne Koskinas Ted Giovanis Foundation for Health and Policy. This will continue support for our work on using lineage tree-based hidden Markov models to quantify the heterogeneity of drug response in tumor cell populations. The project is in collaboration with the Heiser lab at OHSU.

The lab has been awarded a pilot grant from the NCI to combine mechanistic models and AI in the form of autoencoders to model patient-specific phosphoproteomic changes. This is in collaboration with Emek Demir at OHSU, Sara Gosline at PNNL, and Fabian Fröhlich at Harvard.

The lab has been awarded a grant from the NIH National Institute of Allergy and Infectious Diseases. This project builds on our model of IgGs binding to effector cells, to predict the effect of antibody combinations. The work is in collaboration with the Nimmerjahn lab at FAU Erlangen, and has has potential application to many diseases and therapies. As part of this funding, we will also participate in a consortium of labs working to improve antibody engineering.

Welcome to Brian Orcutt-Jahns, who is joining the lab for his Ph.D.! Brian is continuing at UCLA where he studied bioengineering.

Dr. Meyer has received a UCLA Faculty Career Development Award!

Welcome to Cyrillus Tan, who is joining the lab for his Ph.D.! Cyrillus is a student in the bioinformatics program, with a background in computer science.

Thanks to the UCLA Hellman Fellows Program for supporting the lab! These funds will go toward supporting our antibody engineering work.

Dr. Meyer spoke about the lab’s work to model antibody effector cell responses at the second annual Antibodies and Complement Conference.

Drs. Meyer and Bae will present at the CSBC’s Inaugural West Coast Symposium.

Congratulations Ryan R on receiving an NSF Graduate Research Fellowship!

The lab has entered a research agreement with Visterra, Inc., to apply a model of the common gamma-chain family cytokines for engineering ligands with new functions. We’re especially excited to turn models into engineered drugs!


Contact

Packages/Lab:

Meyer Lab
University of California, Los Angeles
5031 Engineering V
Los Angeles, CA 90095

Mail/Office:

Aaron Meyer
Department of Bioengineering at UCLA
4121G Engineering V
Los Angeles, CA 90095
Phone: (310) 794-4821