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INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases -

Very interesting approach to disentangle signaling networks using global phosphoproteomic measurements. This novel method infers kinase activity by integrating the scores of two kinase-centric components; overall kinase phosphorylation levels and activation loop phosphorylation, and two substrate-centric components; quantification of experimentally reported kinase-substrate relationships shown in PhosphoSitePlus and levels of kinase substrates predicted by an algorithm–NetworKIN–that performs motif-based predictions to pinpoint kinases responsible for specific phosphorylation events.