envelope external link doi pubmed bioRxiv

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations -

This paper is an exemplary study of phenotypic heterogeneity in drug response as a source of resistance. They observe that individual PC9 lung cancer cells transiently assume a reversibly drug-tolerant state to protect the population from eradication by potential lethal exposures.