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Reprogramming the immunological microenvironment through radiation and targeting Axl -

This work shows that in addition to being a tumor cell-intrinsic resistance factor to ionizing radiation, AXL signaling drives decreased MHC-I abundance and immunosuppressive cytokine expression. The AXL-proximal signaling that drives this effect is not worked out—it would be interesting to know what signaling is involved to determine how specific this is to TAM receptors vs. other kinases.